Per Nuance Technical Support 7-7-10:
Dragon 10 (10.1) does not support Microsoft Office 2010.
Currently there are no plans to update Dragon 10 (10.1) to support Microsoft Office 2010.

Dragon Version 11 will support Microsoft Office 2010.
(when Dragon 11 is released, however there is no announced release date)

Adding to Dragon Facts sage advice... You can pretty much get away with using DNS 10.1 with nearly full functionality along with Select-&-Say support if you go with the 32-bit version of Office 2010 but you'll run into some major headaches if you try to use the 64-bit version of Office.

Just to add a couple of quick points to KnowBrainer's post.

1. Microsoft Office 2010 64-bit is absolutely incompatible with DNS 10.1. Not only will you not be able to dictate into any Microsoft Office 64-bit application, there is no 64-bit Select-and-Say (dgnword.dll, dgnexcel.dll, or dgnoutlook.dll.dll) and Active Accessibility (i.e., being able to Ribbon tabs, Ribbon bar buttons, or any features normally supported by MSAA (Microsoft Active Accessibility)). In addition, there are no Natural Language Command options available for this version. In short, the only thing that you can do with the 64-bit version of Microsoft Office 2010 is manually type and use the mouse.

2. On the other hand, the 32-bit version of Microsoft Office 2010, while not having, or displaying, Natural Language Commands in the Command Browser for this version, virtually all of the Microsoft Office 2007 Natural Language Commands work with Microsoft Office 2010 32 bit. The 32-bit version supports Select-and-Say for Microsoft Word, Excel, and Outlook 2010. The only major change affecting command and control of Microsoft Office 2010 is the "File tab". However, like being able to access the Office button in Microsoft Office 2007, you can access the "File tab" by simply saying "file tab". I have yet to find that I cannot use Microsoft Office 2010 with the same commands for Microsoft Office 2007 (i.e., File tab being the only exception/change). No updates or changes to DNS 10.1 are required in order to fully utilize the Microsoft Office 2010 applications supported (i.e., Microsoft Office 2007 equivalents).

3. I concur with Dragon Facts that the 64-bit version will not be supported until the next release of DNS.

Chuck Runquist
Technical Project Manager
VoiceTeach LLC
Home of VoicePower® Ultimate

"The absence of evidence is not evidence of absence..." attributed to Dr. Carl Sagan